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Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil

High postprandial serum lipid concentrations are associated with increased oxidative stress which, in turn, increases the risk of atherosclerosis. Epidemiological studies correlate lower incidence of cardiovascular disease with adherence to the Mediterranean diet. The aim of this study was to evaluate changes in inflammatory (TXB2 and LTB4) and oxidative stress markers (urinary hydrogen peroxide levels and serum antioxidant capacity), in addition to classic lipid parameters, after a fat-rich meal administered to 12 normolipemic, healthy subjects. Following a Latin square design, subjects were divided into three groups, each one receiving a different kind of oil (extra virgin olive oil; EVOO, olive oil; OO or corn oil; CO, together with 150 g of potatoes), with 2-week washout periods between treatments. Blood samples were drawn at baseline and after 1, 2, and 6 h after the meal. A significant decrease in inflammatory markers, namely TXB2 and LTB4, after 2 and 6 h after EVOO (but not OO or CO) consumption and a concomitant increase of serum antioxidant capacity were recorded. These data reinforce the notion that the Mediterranean diet reduces the incidence of coronary heart disease partially due to the protective role of its phenolic components, including those of extra virgin olive oil.

Trial
Journal Ref. Bogani P, et al: Atherosclerosis 2007, 190:181-186.
Intervention Drug - 50mg Extra virgin olive oil together with 150g of potatoes
Number of sites 1
Countries involved 1
Sample size 12
Type of statistical analyses intention-to-treat
Risk of bias Overall: Unclear details
Participant characteristics Age: 25 ± 3
Condition: Adherence to Mediterranean diet
Baseline severity: normolipedemic healthy subjects
Duration of trial Unclear 2005 2 weeks plus 6 hours
Primary outcome composite - blood anti-inflammatory markers (TXB2 and LTB4) and oxidative stress markers (urinary hydrogen peroxide)
Effect Measures
Events Intervention Total Events Control Total Risk Diff.
1 1 1 1 0.00 %
A significant decrease in inflammatory markers, namely TXB2 and LTB4, after 2 and 6 h after EVOO (but not OO or CO) consumption and a concomitant increase of serum antioxidant capacity were recorded.
Show Score Ranges

Scores:

(shows median if more than one score was entered)

Elig. Recr. Setting Org. Int. Flex. Del. Flex. Adherence Follow-Up Prim. Out. Prim. An.
1 2 1 1 1 1 1 1 5