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Trials

Title of trial Journal Ref. Intervention PRECIS-2 wheels
  Cimetidine in patients with gastric ulcer: a multi-centre controlled trial Frost F et al. Drug - cimetidine 1g/day
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  Reducing hospital admission through computer supported education for asthma patients. Grampian Asthma Study of Integrated Care (GRASSIC) Osman LM et al. Behavioural change (patients) - four printed booklets on asthma management covering both regular control and action in acute episodes
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  Nicardipine versus nitroprusside for breakthrough hypertension following carotid endarterectomy Dorman T et al. Drug - administration of nicardipine or nitroprusside
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  The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients Aronson S et al. Drug - IV clevidipine
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  Postoperative hypertension: a multicenter, prospective, randomized comparison between intravenous nicardipine and sodium nitroprusside Halpern NA et al. Drug - administration of iv nicardipine or sodium nitroprusside
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  Achieving lipid goals in real life: the Dutch DISCOVERY study Bots AFE et al. Drug - 12 week treatment with Rosuvastatin 10mg
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  Comparison of effects on low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia Davidson M et al. Drug - 12 week treatment with Rosuvastatin 10mg
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  Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil Bogani P et al. Drug - 50mg Extra virgin olive oil together with 150g of potatoes
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  The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial Covas MI et al. Drug - Extra Virgin Olive Oil (high phenolic content 366 mg/kg) for 3 weeks with 2 week wash out period
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  A prospective randomized comparison between paclitaxel and sirolimus stents in the real world of interventional cardiology: the TAXi trial Goy J-J et al. Drug - Sirolimus and Paclitaxel Stents for Percutaneous Coronary Intervention (PCA)
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  A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization Morice MC et al. Drug - Sirolimus-eluting stent
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  Incremental cost-effectiveness of drug-eluting stents compared with a third-generation bare-metal stent in a real-world setting: randomised Basel Stent Kosten Effektivitats Trial (BASKET). Kaiser C et al. Drug - third generation drug-eluting stents
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  TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions. Grube E et al. Drug - Slow-release Packlitaxel-eluting stent
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  Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice (COMPARE): a randomised trial. Kedhi E et al. Drug - paclitaxel-eluting stents
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  Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial Brady AR et al. Drug - Beta blocker during surgery
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  The effects of perioperative beta-blockade: results of the Metoprolol after Vascular Surgery (MaVS) study, a randomized controlled trial. Yang H et al. Drug - Beta blocker Metropolol 50mg - perioperatively for vascular surgery
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  Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study) Jones P et al. Drug - Arvorvostatin, up to 80mg a day
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  Clinical outcomes in managed-care patients with coronary heart disease treated aggressively in lipid-lowering disease management clinics: the alliance study Koren MJ et al. Drug - Arorvastatin to maximum 80mg/day
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  Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection?--results of a randomized controlled pilot trial Bleidorn J et al. Health services delivery and reconfiguration - GPs use ibuprofen 3 x 400 mg oral in the treatment of uncomplicated urinary tract infection (UTI)
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  Long-term follow-up of participants with heart failure in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) Piller LB et al. Drug - amlodipine (2.5-10 mg/d), lisinopril (10-40mg/d), and chlorthalidone 12.5-25mg/d)
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  Coronary stent restenosis in patients treated with cilostazol Douglas JS et al. Drug - cilostazol 100 mg BID for 6 months
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  Comparison of zotarolimus-eluting and everolimus-eluting coronary stents Serruys PW et al. Drug - Second generation Zotarolimus-eluting resolute stents
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  A randomized controlled trial in second-generation zotarolimus-eluting Resolute stents versus everolimus-eluting Xience V stents in real-world patients: the TWENTE trial von Birgelen C et al. Drug - Zotarolumus-eluting Resolute stents
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  Multicenter randomized trial evaluating the efficacy of cilostazol on ischemic vascular complications after drug-eluting stent implantation for coronary heart disease: results of the CILON-T (influence of CILostazol-based triple antiplatelet therapy ON ischemic complication after drug-eluting stenT implantation) trial Suh J-W et al. Drug - Cilostazol (loading dose 200mg, then 100mg BD for 6 months)
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  ATTMH Abernethy JD et al. Drug - antihypertensive therapy
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  BARRACLOUGH Barraclough M et al. Drug - bendrofluazide with potassium supplement, methyldopa, or debrisoquine
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  HSCSG 1974 Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group. JAMA 1974 et al. Drug - anti-hyptertensive
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  Carter Carter AB et al. Drug - Anti-hypertensive treatment
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  Dutch Dutch et al. Drug - Anti-hyptertensive
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  EWPHB Amery A et al. Drug - Anti hypertensive
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  HOPE Yusuf S et al. Drug - anti-hypertension drug
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  HYVET Beckett NS et al. Drug - Anti-Hypertensive
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  MRC-O Medical Research Council trial of treatment of hypertension in older adults et al. Drug - Anti-hypertensive
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  MRC-TMH MRC trial of treatment of mild hypertension et al. Drug - anti-hypertensive
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  Oslo Helgeland A et al. Drug - Anti-hyptertensive
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  PATS Post-stroke antihypertensive treatment study. A preliminary result. Chin Med J (Engl) 1995 et al. Drug - anti-hypertensive
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  SHEP Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension. The Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group. J Clin Epidemiol 1988 et al. Drug - Anti-hypertensive
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  SHEP pilot Perry HM et al. Drug - Anti-hypertensive
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  SYST-EUR Staessen JA et al. Drug - anti-hypertensives
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  USPHSHCSG Smith WM et al. Drug - Anti-hypertensives
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  TEST Eriksson S et al. Drug - Anti-hypertensive
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  UKPDS Perry HM et al. Drug - Anti-hypertensive
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  VA-1 Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967 et al. Drug - Anti-hypertensives
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  VA-11 Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA 1970 et al. Drug - Anti-hypertensives
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  Wolff Wolff FW et al. Drug - Anti-hypertensive
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  VA-NHLBI Evaluation of drug treatment in mild hypertension et al. Drug - Anti-hypertensives
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  HYVET pilot Bulpitt CJ et al. Drug - Anti-hypertensive
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  Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization Topol EJ et al. Drug - Tirofiban
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  COPERS, Effectiveness and cost-utility of a group self-management support intervention (COPERS) for people with chronic musculoskeletal pain: a randomised controlled trial Carnes D et al. Behavioural change (patients) - Self-management course
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  PALOMA - Drug - ALENDRONATE -vs- PLACEBO
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  GISSI Trial: EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION GRUPPO ITALIANO PER LO STUDIO DELLA STREPTOCHINASI NELL’INFARTO MIOCARDICO (GISSI)* Lancet 1986 Feb 22;1(8478) et al. Drug - Intravenous thrombolytic treatment in acute myocardial infarction
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  The Maintaining Musculoskeletal Health (MAmMOTH) Study Macfarlane et al. Behavioural change (patients) - CBT
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  SPPA trial (A multicenter, assessor-blinded, controlled, randomised, parallel group, superiority, pragmatic trial assessing the effectiveness of daily SMS-reminders in Pharmaceutical Care of older adults with hypertension on improving Patients’ Adherence to blood pressure-lowering medication) not yet published Behavioural change (patients) - SMS reminders of blood pressure-lowering medicines intake
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